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林小喬
職稱: 合聘教授    

學歷:

美國明尼蘇達大學博士

辦公室位置: 化學館R208
辦公室分機: 33437
電子信箱: ​carmay@gate.sinica.edu.tw
個人網站: http://www.ibms.sinica.edu.tw/~carmay/

研究領域:

生物分子模擬之計算、巨分子結構


期刊論文:(After 2012)

  1. The IgE gene in primates exhibits extraordinary evolutionary diversity. Pheidias C. Wu, Jiun-Bo Chen, Shoji Kawamura, Christian Roos, Stefan Merker, Chih-Chin Shih, Ban-Dar Hsu, Carmay Lim, and Tse Wen Chang*. Immunogenetics (2012) 64: 279–287. doi:10.1007/s00251-011-0586-9
     
  2. The Effect of Metal Binding on the Characteristic Infrared Band Intensities of Ligands of Biological Interest. Todor Dudev* & Carmay Lim*, J. Mol. Struct. (2012) 1009: 83–88.doi:10.1016/j.molstruc.2011.09.007
     
  3. Why voltage-gated Ca2+ and bacterial Na+ channels with the same EEEE motif in their selectivity filters confer opposite metal selectivity.Todor Dudev* & Carmay Lim*, Phys. Chem. Chem. Phys. (2012) 14: 12451–12456doi:10.1039/C2CP00036A.
     
  4. Hidden relationship between conserved residues and locally conserved phosphate-binding structures in NAD(P)-binding Proteins. Chih Yuan Wu, Yun-Hao Hua, Yao Chi Chen & Carmay Lim*, JPhys. Chem. B(2012) 116: 5644–5652.
     
  5. DR.bind: A web server for predicting DNA-binding sites from the protein structure based on electrostatics, evolution and geometry. Yao Chi Chen, Jon Wright and Carmay Lim*,Nucleic Acids Res. (2012) 40: W249–56. doi: 10.1093/nar/gks481.
     
  6. Competition among Ca2+, Mg2+, and Na+ for ion channel selectivity filters: Determinants of metal ion selectivity. Todor Dudev* & Carmay Lim*, JPhys. Chem. B (2012) 116: 10703–10714.DOI:10.1021/jp304925a.
     
  7. Calcium Ion Selectivity in Biological Systems.Todor Dudev* & Carmay Lim*, Encyclopedia of Metalloproteins (2013), p. 478–484. Kretsinger, Robert H.; Uversky, Vladimir N.; Permyakov, Eugene A. (Eds.), Springer.

     
  8. Differential Role of the Protein Matrix on the Binding of a Catalytic Aspartate to Mg2+ vs Ca2+. Application to E. coli Ribonuclease H1.C. Satheesan Babu*, Todor Dudev & Carmay Lim*, J. Am. Chem. Soc. (2013) 135: 6541–6548.
     
  9. Protein-protein docking using CHARMM and support vector machine. Application to Ab/Ag Complexes. Jon Wright, Karen Sargsyan, Xiong-wu Wu, Bernie Brooks, and Carmay Lim*,J. Chem. Theory & Comput.(2013) 9: 4186–4194.
     
  10. Factors controlling the role of Zn and reactivity of Zn-bound cysteines in proteins: Application to drug target discovery. Yu-Ming Lee, Yeh-fon Lin, and Carmay Lim*, J. Chin. Chem. Soc. (2013) in press. doi: 10.1002/jccs.201300392
     
  11. Identification of labile Zn-sites in promising drug-target proteins.Yu-Ming Lee, Yi-Ting Wang, Yulander Duh, Hanna S. Yuan* and Carmay Lim*, J. Am. Chem. Soc. (2013) 135: 14028-14031.
     
  12. Competition among metal ions for protein binding sites: Determinants of metal ion selectivity in proteins. Todor Dudev* & Carmay Lim*, Chem. Reviews (2013)

     
  13. Identifying RNA–Binding Residues based on Evolutionary Conserved Structural and Energetic Features. Yao Chi Chen, Karen Sargsyan, Jon D. Wright, Yi-Shuian Huang* & Carmay Lim*, Nucleic Acids Res.(2014) 42:e15.
     
  14. Factors Controlling the Role of Zn and Reactivity of Zn-bound Cysteines in Proteins: Application to Drug Target Discovery. Yu-Ming Lee, Yeh-fon Lin, and Carmay Lim*, J. Chin. Chem. Soc. (2014) 61:142-150.
     
  15. Competition among metal ions for protein binding sites: Determinants of metal ion selectivity in proteins. Todor Dudev* & Carmay Lim*, Chem. Rev. (2014) 114:538-556.
     
  16. Potential therapeutic antibodies targeting intrinsically disordered regions in membrane-bound IgE in human B lymphocytes. Hsing-Mao Chu, Jon Wright, Yueh-Hsuan Chan, Chien-Jen Lin, Tse Wen Chang* and Carmay Lim*, Nature Communications (2014), doi:10.1038/ncomms4139
     
  17. Evolution of Eukaryotic Ion Channels: Principles Underlying the Conversion of Ca2+-Selective to Na+-Selective Ion Channels. Todor Dudev* & Carmay Lim*, J. Am. Chem. Soc. (2014)136:3553-3559.

 

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